. Author manuscript; available in PMC: 2008 Mar 5.

Published in final edited form as: Biochem Pharmacol. 2005 Jun 15;69(12):1869–1878. doi: 10.1016/j.bcp.2005.03.030

Table 3.

Kinetics parameters for methadone transfer across term human placental lobule in presence and absence of the P-gp inhibitor GF120918

Parameters	In absence of P-gp inhibitor		In presence of P-gp inhibitor
	AP	Methadone	AP	Methadone
Trf (%)	32.2 ± 6.09	26.8 ± 4.45	31.8 ± 5.83	33.7 ± 6.83^a
Clearance (mL/min)	0.96 ± 0.21	0.79 ± 0.14	0.90 ± 0.15	0.96 ± 0.18^a
Cl index	–	0.84 ± 0.09	–	1.06 ± 0.16^b

P-gp: P-glycoprotein; AP: antipyrine; Trf: fetal transfer rate; Cl: clearance. Each value represents the mean ± standard deviation of eight placental perfusions.

P <.05.

P <.01.