Table 3.

Results of Multivariate Analysis of Selected Prognostic Factors for Overall Survival.

Model and Selected Factor	Hazard Ratio for Death (95% CI)	P Value
Any mutation
Presence of mutation	1.3 (1.0–1.7)	0.04
Primary tumor site
Oral cavity	1.7 (1.2–2.6)	0.005
Hypopharynx	1.8 (1.1–3.1)	0.02
Larynx	1.4 (0.9–2.1)	0.13
Other	1.0 (0.5–2.0)	0.93
Multiple	8.3 (2.4–28.0)	<0.001
Pathologic nodal stage N1–N3	2.4 (1.8–3.3)	<0.001
Treatment
Surgery only	1.4 (1.0–1.9)	0.06
Salvage surgery	2.0 (1.4–2.9)	<0.001
Smoking history	1.1 (1.0–1.2)	0.07
Average alcohol use*
10–32 oz/wk	1.3 (0.9–1.9)	0.11
>32 oz/wk	0.9 (0.6–1.2)	0.39
Unknown	0.5 (0.2–1.0)	0.07
Mutation category
Nondisruptive TP53 mutation	1.1 (0.8–1.6)	0.43
Disruptive TP53 mutation	1.7 (1.2–2.4)	0.003
Primary tumor site
Oral cavity	1.7 (1.2–2.5)	0.006
Hypopharynx	1.9 (1.1–3.2)	0.02
Larynx	1.4 (0.9–2.1)	0.14
Other	1.0 (0.5–2.0)	0.91
Multiple	9.7 (2.8–33.0)	<0.001
Pathologic nodal stage N1–N3	2.4 (1.8–3.3)	<0.001
Treatment
Surgery only	1.4 (1.0–2.0)	0.05
Salvage surgery	2.1 (1.4–3.0)	<0.001
Smoking history	1.1 (1.0–1.2)	0.07
Average alcohol use*
10–32 oz/wk	1.3 (0.9–1.8)	0.13
>32 oz/wk	0.9 (0.6–1.3)	0.41
Unknown	0.5 (0.2–1.0)	0.04

^*To convert values for ounces to milliliters, multiply by 29.6.