Table 1.

Comparison of q and p values for the NCI60 and NCI39 studies. The NCI7 study suggested that the majority of correlates pairs identified in the NCI39 study with a correlation greater than 0.7 were reproducible. This correlation is associated with a q value of 0.05. A similar q value in the NCI60 study is associated with a correlation of just under 0.60. This assessment of acceptable correlations for gene:drug correlates worthy of potential further study is far lower than a conventional correction for multiple hypotheses would suggest.

	p value	Bonferroni corrected p-value	q value	Correlation
'NCI39'	2.4 × 10-4	1	0.2	0.59
	2 × 10-5	1	0.1	0.66
	5.7 × 10-6	1	0.05	0.7
	1.1 × 10-10	0.05	nd	0.84
NCI60	~2 × 10-4	1	0.1	0.5
	1.2 × 10-5	1	0.05	0.57
	5.7 × 10-6	1	0.05	0.59
	1.1 × 10-10	0.05	nd	0.75