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Domain organization of the animal FAS and the DEBS modular PKS. In the FAS, the AT domain is responsible for loading both the starter and chain-elongating substrates, whereas in modular PKSs, these substrates are loaded by separate ATs in the loading and chain-extending modules. The intermediates formed by each of the DEBS modules are shown together with the final 14-membered ring product. The KR domain in module 3 of DEBS is inactive.
