Fig. 24.
Revised domain maps for the animal FAS and a modular PKS. The domain maps for the loading module (LM) and six extender modules of DEBS include the interpolypeptide docking domains (cross-hatched). The KR domain of module 3 is inactive. In both the FAS and modular PKS, the region previously referred to as the central core is assigned to the KR structural subdomain (KRs) and, where present, the second subdomain of the DH. Thus the KR catalytic (KRc) and structural subdomains are contiguous in DEBS modules 1, 2, 3, 5 and 6, but are split by the ER domain in module 4 and in the FAS.