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. 2008 Mar 19;3(3):e1831. doi: 10.1371/journal.pone.0001831

Table 1. Examples of cross-reactive epitopes reported in the literature.

MHC Initial Subsequent Initial Subsequent Overlap Id SO SE Ref.
H2-Kd LCMV NP PV NP YTVKYPNL YTVKFPNM YTVK.PN. 6/8 0.92 0.81 [27]
H2-Kd LCMV NP VV P1 YTVKYPNL YNSLYPNV Y...YPN. 4/8 0.71 0.68 [17]
H2-Kd LCMV NP VV P10 YTVKYPNL STLNFNNL .T....NL 3/8 0.58 0.48 [17]
H2-Kd LCMV NP VV A11R YTVKYPNL AIVNYANL ..V.Y.NL 4/8 0.61 0.58 [28]
H2-Kd LCMV NP VV A11R AVYNFATC AIVNYANL A..N.A.. 3/8 0.61 0.45 [28]
H2-Kd LCMV NP VV A11R ISHNFCNL AIVNYANL ...N..NL 3/8 0.53 0.48 [28]
H2-Kd RSV5 M2-82 RSV M2-71 SYIGSINNI EYALGVVGV .Y....... 1/9 0.46 0.36 [29]
H2-Kd CTL agonist (APL) IGRP206-214 KYNKANWFL VYLKTNVFL .Y.K.N.FL 5/9 0.6 0.64 [30]
H2-Kd Dengue 2 NS3-298 Dengue 3 NS3-299 GYISTRVEM GYISTRVGM GYISTRV.M 8/9 0.9 0.92 [31]
HLA-A2 EBV BMLF1-280 FLU A M1-58 GLCTLVAML GILGFVFTL G....V..L 3/9 0.53 0.47 [32]
HLA-A2 EBV BMLF1-280 FLU A NP-85 GLCTLVAML KLGEFYNQM .L....... 1/9 0.38 0.28 [20]
HLA-A2 EBV BMLF1-280 EBV LMP2 GLCTLVAML LLWTLVVLL .L.TLV..L 5/9 0.62 0.59 [20]
HLA-A2 EBV BMLF1-280 EBV BRLF1 GLCTLVAML YVLDHLIVV ......... 0/9 0.32 0.22 [20]
HLA-A2 FLU A NA-231 HCV NS3-1073 CVNGSCFTL CVNGVCWTV CVNG.C.T. 6/9 0.83 0.78 [33]
HLA-A2 FLU A M1-58 EBV EBNA3A-596 GILGFVFTL SVRDRLARL ........L 1/9 0.38 0.29 [20]
HLA-A2 HPV 16 E7-11 Coronavirus NS2-52 YMLDLQPET TMLDIQPED .MLD.QPE. 6/9 0.79 0.76 [34]
HLA-A2 HIV ENV GP-120 M. tuberculosis VPTDPNPPEV VLTDGNPPEV V.TD.NPPEV 8/10 0.79 0.8 [35]
HLA-B62 Dengue 2 NS3-71 Dengue 3 NS3-71 DVKKDLISY SVKKDLISY .VKKDLISY 8/9 0.92 0.9 [36]
HLA-A1 Hantaanvirus (Sin) Hantaanvirus (Seoul) ISNQEPLKL ISNQEPMKL ISNQEP.KL 8/9 0.97 0.93 [37]

The columns are as follows: 1) MHC restriction, 2) source pathogen and protein for initial infection, 3) source pathogen and protein for subsequent infection, 4) original epitope of initial infection, 5) cross-reactive epitope for subsequent infection, 6) sequence overlap between the cross-reactive epitopes, 7) sequence identity (Id), 8) observed peptide similarity SO and 9) expected peptide similarity SE (for definitions of SO and SE see the main text) 10) reference to the experimental work. Some infectious agents are indicated with abbreviated names and these are: LCMV: Lymphocytic choriomeningitis virus, PV: Pichinde virus (PV), VV: Vacinia virus, EBV: Epstein-Barr virus, RSV: Respiratory synthical virus, HCV: Hepatitic C virus, and HPV: Human papiloma virus.