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. 2008 Mar 6;118(4):1578–1583. doi: 10.1172/JCI34599

Figure 2. Cloning of CFTR-targeted ferrets.

Figure 2

(A) Cloned CFTR-targeted ferrets. The top left panel shows the first clone (sable coat color) at 5 weeks of age with its albino noncloned foster sibling. The other panels show sable clones with ages indicated. (B) Southern blot analysis of ear fibroblast DNA from the 8 CFTR-targeted cloned ferrets (nos. 1–8) using AflII-digested genomic DNA and the indicated CFTR and neomycin probes. NT, nontargeted unrelated ferret DNA. Arrowheads indicate the nontargeted (filled) and gene-targeted (open) CFTR alleles. (C) Preweaning growth rate of CFTR-targeted ferret clones as compared with unrelated noncloned ferrets. Results are shown as the mean ± SEM for the indicated n in each group.