Figure 5.

Effect of p38 inh on production of p24 antigen in HIV-infected PBMC. After infection, PBMC were cultured in R3 medium alone (control) or with added p38 inh at the concentrations shown. Total p24 antigen was measured after 4 days, and values were expressed as percent p24 compared with control cultures (data not shown, set at 100%). Inset compares p24 antigen production in cultures exposed to p38 inh on the first day of incubation (1.0 μM) with cultures receiving inhibitor on each day of incubation (1.0 μM each day). The vertical axis of Inset represents percent production of p24 antigen compared with control (100%). Mean ± SEM p24 antigen is shown (n = 7). ∗, P < 0.05 compared with control.