Table 2.
PND30
|
PND60
|
PND100
|
|||||
---|---|---|---|---|---|---|---|
Measure | Region | Male | Female | Male | Female | Male | Female |
ChAT activity (pmol/min per mg protein) | f/p cx | 763 ± 36 | 728 ± 42 | 706 ± 26 | 740 ± 29 | 785 ± 21 | 833 ± 18 |
t/o cx | 454 ± 29 | 458 ± 18 | 624 ± 17 | 595 ± 22 | 560 ± 18 | 592 ± 14 | |
hp | 643 ± 28 | 611 ± 33 | 689 ± 2 | 685 ± 9 | 769 ± 14 | 774 ± 22 | |
st | 573 ± 24 | 539 ± 39 | 864 ± 57 | 973 ± 37 | 1,318 ± 97 | 1,356 ± 63 | |
mb | 775 ± 13 | 770 ± 24 | —a | —a | 620 ± 21 | 681 ± 5* | |
HC3 binding (fmol/mg protein) | f/p cx | 15.9 ± 0.7 | 16.7 ± 1.4 | 14.1 ± 0.4 | 14.3 ± 0.5 | 14.1 ± 0.6 | 13.6 ± 0.8 |
t/o cx | 15.4 ± 0.8 | 15.5 ± 0.5 | 12.8 ± 0.8 | 12.2 ± 0.7 | 13.2 ± 0.4 | 16.5 ± 1.0* | |
hp | 26.6 ± 2.0 | 26.2 ± 1.0 | 19.3 ± 0.4 | 21.9 ± 0.8* | 18.3 ± 0.7 | 17.8 ± 0.9 | |
st | 71 ± 4 | 60 ± 2* | 67 ± 3 | 74 ± 4 | 72 ± 2 | 76 ± 3 | |
mb | 15.2 ± 0.7 | 15.4 ± 1.1 | 12.4 ± 0.3 | 12.9 ± 0.4 | 12.6 ± 0.4 | 12.3 ± 0.6 | |
nAChR binding (fmol/mg protein) | f/p cx | 66 ± 3 | 64 ± 2 | 62 ± 1 | 59 ± 2 | 53 ± 2 | 48 ± 2 |
t/o cx | 87 ± 4 | 78 ± 1 | 70 ± 2 | 70 ± 3 | 63 ± 2 | 66 ± 2 | |
hp | 46 ± 3 | 45 ± 2 | 38 ± 2 | 40 ± 2 | 32 ± 1 | 29 ± 2 | |
st | 88 ± 4 | 72 ± 3* | 72 ± 1 | 68 ± 3 | 61 ± 1 | 60 ± 2 | |
mb | 102 ± 3 | 96 ± 3 | 74 ± 3 | 71 ± 1 | 67 ± 2 | 67 ± 2 |
Abbreviations: f/p cx, frontal/parietal cortex; hp, hippocampus; mb, midbrain; st, striatum; t/o cx, temporal/occipital cortex. Data are means ± SEs obtained from six animals of each sex at each age.
ChAT is missing because of a technical error for the samples on that day.
Females significantly different from males.