Table 2.

Control values for cholinergic markers.

		PND30		PND60		PND100
Measure	Region	Male	Female	Male	Female	Male	Female
ChAT activity (pmol/min per mg protein)	f/p cx	763 ± 36	728 ± 42	706 ± 26	740 ± 29	785 ± 21	833 ± 18
	t/o cx	454 ± 29	458 ± 18	624 ± 17	595 ± 22	560 ± 18	592 ± 14
	hp	643 ± 28	611 ± 33	689 ± 2	685 ± 9	769 ± 14	774 ± 22
	st	573 ± 24	539 ± 39	864 ± 57	973 ± 37	1,318 ± 97	1,356 ± 63
	mb	775 ± 13	770 ± 24	—a	—a	620 ± 21	681 ± 5*
HC3 binding (fmol/mg protein)	f/p cx	15.9 ± 0.7	16.7 ± 1.4	14.1 ± 0.4	14.3 ± 0.5	14.1 ± 0.6	13.6 ± 0.8
	t/o cx	15.4 ± 0.8	15.5 ± 0.5	12.8 ± 0.8	12.2 ± 0.7	13.2 ± 0.4	16.5 ± 1.0*
	hp	26.6 ± 2.0	26.2 ± 1.0	19.3 ± 0.4	21.9 ± 0.8*	18.3 ± 0.7	17.8 ± 0.9
	st	71 ± 4	60 ± 2*	67 ± 3	74 ± 4	72 ± 2	76 ± 3
	mb	15.2 ± 0.7	15.4 ± 1.1	12.4 ± 0.3	12.9 ± 0.4	12.6 ± 0.4	12.3 ± 0.6
nAChR binding (fmol/mg protein)	f/p cx	66 ± 3	64 ± 2	62 ± 1	59 ± 2	53 ± 2	48 ± 2
	t/o cx	87 ± 4	78 ± 1	70 ± 2	70 ± 3	63 ± 2	66 ± 2
	hp	46 ± 3	45 ± 2	38 ± 2	40 ± 2	32 ± 1	29 ± 2
	st	88 ± 4	72 ± 3*	72 ± 1	68 ± 3	61 ± 1	60 ± 2
	mb	102 ± 3	96 ± 3	74 ± 3	71 ± 1	67 ± 2	67 ± 2

Abbreviations: f/p cx, frontal/parietal cortex; hp, hippocampus; mb, midbrain; st, striatum; t/o cx, temporal/occipital cortex. Data are means ± SEs obtained from six animals of each sex at each age.

^aChAT is missing because of a technical error for the samples on that day.

^*Females significantly different from males.