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. 2007 Dec 20;116(3):349–354. doi: 10.1289/ehp.10722

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Kinetics of serum SEAP in DRESSA mice exposed to TCDD. (A) Serum SEAP activity in wild-type (WT, n = 2) and DRESSA25 (DRESSA, n = 5) mice after oral administration of 5 μg/kg bw TCDD. (B) Dose-dependent responses of serum SEAP in DRESSA25 mice exposed to 0.1–5 μg/kg bw TCDD. Fold induction of SEAP vs. basal level is shown (n = 4–5 mice). (C) Sex-dependent difference in the response to TCDD. Age-matched male (n = 27) and female (n = 22) DRESSA25 mice were exposed to 5 μg/kg bw TCDD, and activity of serum SEAP was evaluated. Data are presented as mean ± SE.

*Statistically significant difference, p < 0.05.