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Curve classification and potency distribution of the NTP 1,408 compounds in rat primary kidney proximal tubule cells.
| Curve classificationa |
||||||
|---|---|---|---|---|---|---|
| IC50 range | 1a | 1b | 2a | 2b | 3 | 4 |
| < 100 nM (%) | 1 (0.07) | 2 (0.1) | 0 | 0 | 0 | |
| 1 μM–100 nM (%) | 5 (0.4) | 0 | 0 | 0 | 0 | |
| 10 μM–1 μM (%) | 10 (0.7) | 0 | 0 | 4 (0.3) | 0 | |
| 80 μM–10 μM (%) | 23 (1.6) | 7 (0.5) | 30 (2.1) | 71 (5.0) | 21 (1.5) | |
| > 92 μM (%) | 1,233 (87.6) | |||||
See “Materials and Methods” for curve class definitions.
