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. 2008 Feb 22;105(9):3449–3454. doi: 10.1073/pnas.0712126105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 6. — Vangl1^gt/+;Vangl2^lp/+ embryos exhibit aberrant right subclavian artery. (A) Vangl1 expression in fourth aortic arch of E10.5 Vangl1^gt/gt embryo (X-gal staining; magnification, ×600). (B) X-Gal staining of the intracardiac structures of the of E10.5 Vangl1^gt/gt embryos (magnification, ×200). (C and D) Transverse sections through the hearts of E14.5 embryos (magnification, ×400). (C) In WT embryos, the right subclavian artery (arrows) is positioned laterally from trachea and esophagus. In Vangl2^lp/lp embryos (D) and in Vangl1^gt/+;Vangl2^lp/+ (E), the right subclavian artery is positioned dorsal to esophagus. (F and G) Three-dimensional reconstruction of the arteries of E14.5 WT (F) and Vangl1^gt/+;Vangl2^lp/+ hearts (G). Ao, aorta; DAo, dorsal aorta; E, esophagus; LV, left ventricle; PAA, pharyngeal arch artery; PV, pulmonary valve; RA, right atrium; rsca, right subclavian artery; RV, right ventricle; T, trachea; Th, thymic primordium.