Fig. 3.

Region-specific signatures of DNA instability and allele expression. Shown is a comparison of CAG repeat traces from DNA and RNA that have been extracted from the striata of the same R6/1 mouse at 9 months of age (n = 3). As for DNA, the region-specific RNA traces are consistent between mice. The DNA and RNA CAG repeat ranges are comparable and are composed of a number of peaks indicative of the multimodal nature of the radical component. The position but not the relative height of the peaks is conserved between the DNA and RNA traces. Therefore, the relative RNA allele abundance is the product of mode-specific expression levels. Note that there is no consistent relationship between the repeat length and respective expression level. Blue traces, DNA; red traces, RNA.