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. 2008 Feb 27;105(9):3345–3350. doi: 10.1073/pnas.0712287105

Fig. 7.

Fig. 7.

The presence of AQP5 alters shear-induced changes in paracellular permeability. (A) 16HBE cells expressing Adeno-hAQP5 were exposed to static or shear conditions. AQP5 expression decreased after 2 h of shear stress. (B) 16HBE cells infected with Adeno-GFP virus or Adeno-hAQP5 were exposed to static or shear. Presence of Adeno-hAQP5 caused increased paracellular permeability, compared with either infection with a GFP control or an uninfected control. After the application of shear stress, Adeno-hAQP5-expressing cells had significantly decreased paracellular permeability, compared with static conditions (n = 3). *, P < 0.05 with ANOVA one-way Bonferroni correction. (C) 16HBE cells were infected with Adeno-GFP virus or Adeno-hAQP5 under static and shear condition. Actin fibers were assessed by using Texas-red phalloidin. Only hAQP5-expressing cells had altered actin expression and desmoplakin redistribution in response to shear stress.