Fig. 4.

MKP-4 overexpression reduces hyperglycemia and improves glucose intolerance in ob/ob mice. Ten-week-old ob/ob mice were infected with AdV-GFP (n = 5, gray) or AdV-MKP-4 (n = 6, black) via tail vein injection. (A and B) Fed (A) and fasting (B) blood glucose levels were measured 2 days after adenovirus injection. (C) An i.p. glucose tolerance test (GTT) was performed on day 5 after a 6-h fast. (D) The area under the curve was estimated by summing the numerical integration values of successive linear segments of the glucose curve for 0–15, 15–30, 30–60, and 60–120 min.