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. 2008 Feb 22;105(9):3545–3550. doi: 10.1073/pnas.0712275105

Fig. 5.

Fig. 5.

Effects of MKP-4 on gene expression and lipid accumulation in liver of ob/ob mice. (A) Gene-expression analysis was performed on liver extracts from 10-week-old control C57BL6 mice (n = 6, white bars) and ob/ob mice infected with AdV-GFP (n = 11, gray bars) or AdV-MKP-4 (n = 12, black bars). Hepatic expression of various genes was analyzed by real-time PCR. Expression levels were normalized to TBP and presented as the mean ± SEM. *, P < 0.05; **, P < 0.01. (B) Hematoxylin and eosin staining of liver section is shown at magnification ×40. (C) The triglyceride content in the liver of mice infected with AdV-GFP (n = 5, gray bars) or AdV-MKP-4 (n = 6, black bars) was measured as specified in Experimental Methods and presented as the means ± SEM. *, P < 0.05.