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. Author manuscript; available in PMC: 2008 Dec 14.
Published in final edited form as: Brain Res. 2007 Sep 22;1185:256–265. doi: 10.1016/j.brainres.2007.09.034

Figure 2. AAV2 IGF-1 delivery delayed hindlimb grip strength decline and weight loss selectively in male SOD1G93A mice.

Figure 2

Injections of either AAV2 GFP or AAV2 IGF-1 did not result in weight loss or decline in hindlimb grip strength in wild-type mice (A–B). Furthermore, there were no differences in weight or hindlimb grip strength values between AAV2 GFP and AAV2 IGF-1 wild-type mice (A–B). No change in hindlimb grip strength decline was noted for female SOD1G93A mice (D), while a significant delay in grip strength decline was seen in male SOD1G93A mice (C). In male SOD1G93A mice, AAV2 IGF-1 significantly delayed weight decline compared to AAV2 GFP controls at 8, 9 and 10 weeks post-injection (E). Compared to AAV2 GFP controls, AAV2 IGF-1 injections had no effect on weight decline in female SOD1G93A mice (F).