Table 4.

Unadjusted Odds Ratios, multinomial logistic regression, for covariates on wheeze phenotypes

	Early-transient	Early-onset persistent	Late-onset
Covariate	OR, p-value	OR, p-value	OR, p-value
rs1800925, CT-TT vs CC	0.99, 0.971	0.98, 0.928	0.91, 0.743
rs2066960, CA-AA vs CC	1.61, 0.032	1.36, 0.273	1.24, 0.524
rs1295686, CT-TT vs CC	1.02, 0.922	1.12. 0.642	1.02, 0.937
rs20541, GA-AA vs GG	1.17, 0.393	1.12, 0.614	1.55, 0.096
rs1295685, GG vs GA-AA	1.16, 0.411	1.15, 0.535	1.51, 0.116
others vs CCG/CCG	1.10, 0.592	0.93, 0.729	1.10, 0.709
ETS-2 vs ETS-0	1.70, 0.022	2.93, <0.0001	0.57, 0.173
ETS-1 vs ETS-0	1.57, 0.023	1.86, 0.018	0.61, 0.861

‡ The reference was the group who never report wheeze up to age 10 (n = 426).

CCG/CCG is the most common haplotype pair constructed based on rs1800925, rs2066960 and rs20541, using PHASE 2.0.2 software [34]. ETS-0, mothers did not smoke during pregnancy and children not exposed to household ETS; ETS-1, mothers did not smoke during pregnancy, but children were exposed to household ETS; ETS-2, mothers smoked during pregnancy and children were exposed to household ETS