Table 2. Mouse infections with RNA viruses.

Virus	Route	Mouse strain	Mouse Age (weeks)	Infected Mice (n = )	Days p.i.	Organs	Figure
LDV	i.p.	C57BL/6	3–4	9	1a	Brain-Liver	2 A.
MHV-A59	i.c.	C57BL/6	3–4	10	3b	Brain-Liver	2 B.
TMEV-DA1	i.c.	129/Sv	3–4	2	5c	Brain	2 C.
LACVdelNSse	i.p.	B6.A2G-Mx1	6	2	7b	Brain	2 D.
TMEV-GDVIIe	i.c.	FVB/N	3–4	2	5b	Brain	2 E.
TMEV-GDVII	i.c.	C57BL/6	3–4	6	4b	Brain	2 F.
MHV-A59	i.p.	C57BL/6	3–4	7	2d	Liver	2 G.
MHV-A59	i.p.	129/Sv	5	3	2d	Liver	2 H.

^a1 day post-infection was reported to correspond to the peak of LDV replication and of IFN expression in vivo.

^bMice infected with highly neurovirulent viruses were sampled when signs of encephalitis were prominent (generally less than 24 hours before death).

^cThe DA1 strain of TMEV produces a transient encephalitis lasting about 1 or 2 weeks. In mice with the H-2 b haplotype, the virus is then rapidly cleared by the cytolytic T lymphocyte response [40],[41]. Mice were sampled at 5 days post-infection, a time-point representative of the acute phase of infection.

^dPreliminary RT-PCR experiments failed to reveal a clear difference in IFN expression and viral load between 129/Sv mice infected i.p. for 2 days and for 7 days. Only mice with amounts of MHV-A59 detectable by conventional RT-PCR were taken into account.

^eThese samples from TMEV (GDVII strain) and LACVdelNSs infected brains were from a previous work [33].