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. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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WT C57BL/6 (open squares) and CAT2^−/− (filled circles) mice were infected with 30–35 S. mansoni cercariae and sacrificed on wk 8, 12 and 24 post-infection. A. Liver Fibrosis adjusted per worm pair (µmol of hydroxyproline/worm pair). The * symbol denotes significant differences between WT and KO mice at that time point, p<0.05. B. Liver Fibrosis per 10,000 eggs (µmol of hydroxyproline/1×10⁴ eggs). C. Representative liver granulomas stained with Masson's Trichrome (8 wk infected C57BL/6 mouse). D. Representative liver granulomas stained with Masson's Trichrome (8 wk infected CAT2^−/− mouse). The bar in panel 3D = 200 microns.