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. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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WT C57BL/6 (squares) and CAT2^−/− (circles) mice were infected with 30–35 cercariae. Separate groups were treated with either control antibody (C Ig, open symbols) or with a neutralizing mAb to IL-13 (α-IL-13, filled symbols) weekly for a total of 4 wk starting on wk 5 post-infection. The animals were sacrificed on wk 9 and fibrosis and granuloma formation were assessed. A. Liver hydroxyproline levels in individual mice, shown as µmol/liver, µmol/worm pair, and µmol/10K eggs. Significant differences are indicated in each figure. B. Granuloma size (volume, mm³ × 10⁻³), percentage of granuloma-associated eosinophils, and mast cell indices were determined microscopically.