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. 2008 Mar 14;4(3):e1000023. doi: 10.1371/journal.ppat.1000023

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. WT C57BL/6 (open squares), CAT2^−/− (filled circles), NOS2^−/− (filled inverted triangles) and IFN-γ^−/− (filled triangles) mice were infected i.p. with 20 T. gondii cysts, and survival was assessed up to 50 days post-infection. (N = 5/group). B. Peritoneal exudate cells (PECs) were prepared from WT and CAT2^−/− mice on day 7 post-infection. The percentage of infected cells was determined microscopically by evaluating a minimum of 700 cells per slide (3 mice/group). C. PECs were placed in culture for 24–48 hr and either left untreated or restimulated with STAG. Culture supernatants were collected and IFN-γ levels were determined by ELISA. D. NO activity was evaluated in the same culture supernatants by measuring nitrate production.