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. 2008 Mar 19;2(3):e199. doi: 10.1371/journal.pntd.0000199

Figure 1. Spleen cell IL-2 (A) and IFN-γ (B) responses to RPMI medium (grey bars), recombinant Ag85A from M. ulcerans (white bars) and M. tuberculosis (black bars) in B6 mice vaccinated with Ag85A DNA, Ag85A protein or Ag85A DNA boosted with protein in Gerbu adjuvant, 3 months after the third immunization.

Figure 1

Cytokines levels tested on 24 h (IL-2) and 72 h (IFN-γ) culture supernatant of 4 mice tested individually/group. Data presented as means±SDs intra-assay. Statistically significant results as compared to the DNA vaccinated M. ulcerans or M. tuberculosis groups are represented in the figure by *** (P<0.001), ** (P<0.01) and * (P<0.05). The first group of comparison take all of the vaccinated mice compared to the DNA vaccinated mice in response to recombinant Ag85A from M. ulcerans. The second group of comparison take all of the vaccinated mice compared to the DNA vaccinated mice in response to recombinant Ag85A from M. tuberculosis.