Table 1. Parameter values used in both stochastic and deterministic simulations.
Constant | Value | Description |
Rm | 0.57 Ωm2 | membrane resistance |
Cm | 0.03 F/m2 | membrane capacitance |
Em | −0.025 V | equilibrium membrane potential |
+0.07 V | equilibrium potential for Na+ | |
−0.075 V | equilibrium potential for K+ | |
+0.14 V | equilibrium potential for Ca2+ | |
−0.085 V | equilibrium potential for BKCa | |
B | 5.2⋅10−6 mol/C | constant for Ca2+ transfer into the cell |
[Ca2+]rest | 100⋅10−6 mol/m3 | [Ca2+] at rest |
τCa | 1⋅10−3 s | time constant for the decay of |
intracellular free calcium | ||
dcell | 6⋅10−6 m | diameter of the granule cell |
dshell | 1⋅10−7 m | diameter of the shell defining the volume |
in which calcium ions are processed | ||
400 S/m2 | maximal conductance for NaF | |
120 S/m2 | maximal conductance for KDr | |
10 S/m2 | maximal conductance for KA | |
28 S/m2 | maximal conductance for Kir | |
4.6 S/m2 | maximal conductance for CaHVA | |
30 S/m2 | maximal conductance for BKCa | |
3 | exponential for NaF activation | |
1 | exponential for NaF inactivation | |
4 | exponential for KDr activation | |
3 | exponential for KA activation | |
1 | exponential for KA inactivation | |
1 | exponential for Kir activation | |
2 | exponential for CaHVA activation | |
1 | exponential for CaHVA inactivation | |
1 | exponential for BKCa activation |
See the sections Deterministic Model and Complete Stochastic Model for more details on ion channel types and the description of the complete mathematical model.