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. 2008 Feb 29;4(2):e1000022. doi: 10.1371/journal.pgen.1000022

Figure 2. Fragmented Mitochondria Caused by RNAi or Mutations in eat-3.

Figure 2

(A) Regular tubular array of mitochondria in muscle cells of a wildtype worm. (B) Fragmented mitochondria in muscle cells subjected to eat-3 RNAi generated with a Pmyo-3:: antisense-eat-3 construct. (C) Fragmented mitochondria in muscle cells of worms with a Pmyo-3:: eat-3(T322A) construct. (D) Fragmented mitochondria in muscle cells eat-3(ad426) worms. (E) Fragmented mitochondria in the muscle cells of eat-3(tm1107) worms. (F) Tubular mitochondria in the muscle cells of eat-3(ad426) worms that were rescued by a construct containing wildtype eat-3 cDNA under control of the eat-3 gene promoter (Ex[eat-3(wt)]). (G) Mitochondria in the fzo-1(tm1133) deletion strain. (H-J) Mitochondria in the eat-3(ad426) revertants cq6, cq8, and cq10. Mitochondria were detected with matrix GFP driven by the muscle specific myo-3 promoter. The bar indicates 5 µm.