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. 2008 Mar 21;4(3):e1000025. doi: 10.1371/journal.pgen.1000025

Figure 2. Overview of the Runt gene evolution in chordates.

Figure 2

The stepwise evolution of cartilage and bone and the most likely time intervals of Runt gene duplications (Dup) are indicated. The position of tunicates is contentious [31] which is indicated by a dashed line. In this context it is of interest that pre-neural crest cells have been observed in tunicates [60].