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. 2008 Feb 25;180(4):681–689. doi: 10.1083/jcb.200710074

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Copyright © 2008, The Rockefeller University Press

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Figure 2. — RUVBL1 is required for ILK localization to the centrosome and its absence leads to mitotic spindle defects. (A) RUVBL1 protein was depleted by RUVBL1 siRNA as shown by Western blot. (B) RUVBL1 siRNA–treated cells. (C) Histogram showing the percentage of disrupted mitotic cells in control and RUVBL1 siRNA–treated cells. Data are mean ± SD of three independent experiments in which >100 mitotic cells were counted for each condition. (D) Cells stained with ILK and pericentrin show localization of ILK to centrosomes in control but not RUVBL1 siRNA–treated cells. Bars, ∼10 μm.