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. 2007 Dec 21;8:119. doi: 10.1186/1471-2199-8-119

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Copyright © 2007 Mickle et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genome-wide microarray analysis of DNA re-replication over time in wild-type cells. The relative amplification of sequences was determined by competitive hybridization of DNA from re-replicating cells against DNA from the same strain prior to re-replication. DNA re-replication profiles of wild-type cells induced for 17 hours, 21 hours, and 25 hours are shown for chromosomes 1 (A), 2 (B), and 3 (C). Centromeres are indicated by yellow squares. No smoothing of data has been applied. Vertical lines indicate the relative level of DNA amplification across the genome. A value of 1.0 is the average amount of re-replicated DNA for the genome. Values greater than 1.0 represent probes which were replicated more than the average amount of re-replication. The results reveal a gradual increase in differences between the most amplified and least amplified regions over time.