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. 2008 Jan 31;27(5):770–781. doi: 10.1038/emboj.2008.14

Figure 1.

Figure 1

FA embryos have a reduced neocortex size. Embryonic brains (E14.5) were cut into coronal sections at different rostro-caudal levels (I, II, III) as shown in the sagittal representation. (A) A typical DAPI staining of caudal sections (III) is shown for fancg+/+ and fancg−/− brains. (A′) βIII-Tubulin (red) and nestin (green) immunostainings corresponding to white boxes on the left panel. (B, C) Neocortices of fanca−/− and fancg−/− showed a size reduction in the dorsal pallium (DP boxes in A′) compared with WT controls at each rostro-caudal level. (D, E) The thickness of the βIII-tubulin zone, containing neurons, was decreased in dorsal pallium of the fanca−/− and fancg−/− neocortex compared with WT controls at each rostro-caudal level. The number of mice is indicated within the bars. V, ventricle. Scale bars, 100 μm. *P<0.05; **P<0.01; ***P<0.005.