Figure 4.

Apoptosis is increased in the adult FA SVZ. (A) Pycnotic nuclei and cleaved-caspase-3 staining (white arrows) are shown in the SVZ of adult fancg^−/− mice. Colocalization of pycnotic nuclei and cleaved-caspase-3 staining is showed in an enlargement (lower panel). (B) Quantifications of cleaved-caspase-3-positive cells per SVZ cross section showed significant elevated apoptosis in the SVZ of fanca^−/− and fancg^−/− compared with fanca^+/+ and fancg^+/+ controls. The number of mice is indicated within the bars. V, ventricle. ^***P<0.005.