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. Author manuscript; available in PMC: 2009 Feb 19.
Published in final edited form as: Neuroscience. 2008 Jan 16;151(4):1034–1041. doi: 10.1016/j.neuroscience.2007.12.015

Fig. 2.

Fig. 2

NGF activates P2 through an AP2 site. (A) AP2 site is a functional positive element. The maps of reporter constructs are shown on top: K18 for the full-length P2, K18m for the specific AP2 site mutant of K18, and Kd50 for deletion mutant carrying only the AP2 site. Reporter genes were introduced into P19 cells and luciferase activity as well as internal controls was measured. (B) AP2 site mediates the stimulating effects of NGF. Reporter genes were introduced into P19 cells and luciferase activity as well as internal controls was measured. NGF effect was determined by normalizing the luciferase reading over the internal control for each reporter construct. The data of averages and SDs were collected from three independent experiments. Column NGF *p<0.01, versus No NGF for both constructs.