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OVA-IC are at least 100 times more efficient then soluble OVA in inducing T-cell proliferation. CFSE labelled DO11·10 cells were transferred into mice. These mice were subsequently injected i.v. with different concentrations of soluble OVA or OVA complexed to anti-OVA IgG (n = 2). Three days after injection, proliferation of the DO11·10 cells (CD4+/KJI26+) was analysed in the spleen and lymph nodes (not shown). One representative experiment out of two performed is presented.
