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DC and/or macrophages are the predominant cells for presentation of IgG-complexed OVA to OVA-specific CD4+ T cells in vivo. CFSE-labelled DO11.10 cells were transferred into wild-type (a) or CD11c-DTR transgenic mice (b) These mice were or were not treated with DT, as indicated, and injected i.v. with 1 µg IC (n = 2). Three days after IC injection, proliferation of the DO11.10 cells (CD4+/KJI26+) was analysed. One representative experiment out of two performed is presented.
