Table 2.

TB vaccination/challenge studies in MHC class II^–/– mice

	Log10 CFU of M. tuberculosis (mean ± SEM)2
Group1	Lung	Spleen
Naive	6·88 ± 0·05	6·00 ± 0·17
mc26030	6·27 ± 0·04	5·8 ± 0·20
	(−0·61)*
+ anti-Thy-1.2	8·77 ± 0·04	6·76 ± 0·06
	(+1·89)*	(+0·76)*

¹MHC Class II^–/– mice were vaccinated s.c. with 10⁶ CFU of the mc²6030 vaccine. Two months after vaccination, some of the vaccinated mice were treated i.p. with anti-Thy-1.2 (clone 30-H12) twice before challenge and every 10 days subsequent to being challenged.

²Mean bacterial CFU (log₁₀) (± SEM) in the lungs and spleens of mice 24 days following an aerosol infection with about 200 CFU of M. tuberculosis Erdman per mouse (n = 5). The values in parentheses represent the difference in bacterial burden relative to the naive control mice.

^*P < 0·05.