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. 2007 May;121(1):82–93. doi: 10.1111/j.1365-2567.2007.02540.x

Figure 2.

Figure 2

Proteolytic fragments of MBP after processing with lysosomal extracts. Intact MBP was incubated with lysosomal extracts from resting microglia (microglia; top panel) or IFN-γ-stimulated microglia (microglia + IFN-γ; bottom panel) for 10 hr (a) or 24 hr (b), and the proteolytic fragments obtained were identified by mass spectrometry and displayed along with full-length MBP and the location of the two major immunogenic epitopes (MBP85–99 and MBP116–123). Arrows mark major cleavage sites and the respective flanking amino acids are indicated.