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Postulated Gαi2 and Gαi1/3 regulation of LPS-, SA- and GBS-induced chemokine production in peritoneal macrophages
| Stimuli | G protein | MIP-1α | KC | IP-10 |
|---|---|---|---|---|
| LPS | Gαi2 | = | = | + |
| SA | Gαi2 | − | = | = |
| GBS | Gαi2 | + | + | = |
| LPS | Gαi1/3 | − | = | + |
| SA | Gαi1/3 | − | = | = |
| GBS | Gαi1/3 | = | + | = |
+, mediates increased production; −, negatively modulates production; =, does not participate in production.
