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The effect of SMA-7 on the LPS-induced ceramide accumulation in macrophages. Cells were incubated for 3 hr with LPS alone or with LPS plus SMA-7. Total cellular C16-ceramide was measured by using the LC/MS procedure as described in the Materials and methods. ***P < 0·005, compared to the control. ###P < 0·005, compared to LPS alone.
