Figure 1.

Transfer of CD8⁺γδ T cells abolishes the late response to antigen challenge. (a) Lung resistance measurements over 8 hr are depicted. Each data point represents the mean ± SE. The late airway response was greatly decreased in the CD8⁺γδ T-cell group and this effect was reversed in the IFN-γ depleted CD8⁺γδ T cell group. (b) Early airway responses were defined as the maximal value of lung resistance within the first 60 min of challenge and expressed as a percentage of baseline lung resistance. There was no significant difference in the group means. (c) The late airway response was calculated as the area under the curve of lung resistance against time from 3 to 8 hr, after correction for baseline lung resistance. The CD8⁺γδ T-cell group response was significantly lower compared to the PBS and to the IFN-γ depleted CD8⁺γδ T cell group: P < 0·05. There was no significant difference between the PBS and IFN-γ depleted CD8⁺γδ T-cell group.