Figure 8.

Failure of neutralizing mAbs to TGF-β and IL-10 to restore the CD40L-induced cytokine production and surface marker expression in LPS-pretreated cells. Monocytes were cultured as previously described (see legends to Figs 2 and 7) in the presence or absence of 5 μg/ml anti-TGF-β or anti IL-10 mAbs. Results were calculated as (% of expression in the presence of the neutralizing mAbs)/(% of expression in the absence of neutralizing mAbs) × 100. Data represent the arithmetic means of two experiments carried out with cells from two different donors.