Figure 6.
4-1BB-deletion in MRL-Faslpr (lpr) mice causes acute renal injury. (a, c, e) Frozen sections (7 µm) of kidneys were stained with haematoxylin and eosin (H & E) (a) or with the indicated fluorescein isothiocyanate (FITC)-conjugated antibodies (c, e). (b) Infiltrating cells in each glomerulus were visually counted under a microscope. A minimum of at least 10 glomeruli were counted and expressed as mean ± standard deviation. (d, f) Staining of kidney sections was performed and titres of immunoglobulin G (IgG) and C3 assessed as described in the Materials and methods. Magnification ×18. *P < 0·001.