Table 1.

levels of IL-12p40, IL-12p70 and IL-23 in serum and spleen at steady state in IL-12p40 TG mice and control littermates

	Control mice	IL-12p40 tg mice
IL-12p40
Serum (ng/ml)	0·01 ± 0·01	129 ± 24**
Spleen (ng/organ)	0·13 ± 0·03	75 ± 13*
IL-12p70
Serum (pg/ml)	<2–3	38 ± 8*
Spleen (pg/organ)	29 ± 7	47 ± 5*
IL-23
Serum (pg/ml)	10 ± 5	53 ± 15*
Spleen (pg/organ)	164 ± 66	653 ± 198

Amounts of cytokines were determined by ELISA in the different strains of mice and are expressed as means ng of IL-12p40 or pg of IL-12p70 and IL-23/ml of serum or/organ ± SEM of 12–15 animals per group

^*(P < 0·005 and

^**P < 0·00001).