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Methylation of hMSH2 in primary sporadic colorectal cancer. The presence of a visible PCR product in those lanes marked U indicates the presence of unmethylated genes of hMSH2; the presence of product in those lanes marked M indicates the presence of methylated genes, seen only in the in vitro methylated control DNA (∗). All primary colorectal tumors contain only unmethylated hMSH2 genes.
