Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Sep;126(3):227–241. doi: 10.1085/jgp.200509321

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 2. — Chimeric channels of mSlo1 and dSlo1 retain features of their native WT channels. (A, top) Current traces of Chim2 and mSlo1 at [Ca²⁺]_i of 2, 10, and 100 μM. Test potentials were −80 to +200 mV, holding and repolarization potentials were −50 mV. (Bottom) Steady-state G-V relations of Chim2 and mSlo1. Smooth curves are fits of the Boltzmann equation with parameters for Chim2, in 2 μM [Ca²⁺]_i: V_1/2 = 240.1 mV, z = 0.95, in 10 μM [Ca²⁺]_i: V_1/2 = 76.1 mV, z = 1.5, in 100 μM [Ca²⁺]_i: V_1/2 = 43.5 mV, z = 1.5; for mSlo1, in 2 μM [Ca²⁺]_i: V_1/2 = 84.8 mV, z = 1.5, in 10 μM [Ca²⁺]_i: V_1/2 = 31.4 mV, z = 1.5, in 100 μM [Ca²⁺]_i: V_1/2 = 14.4 mV, z = 1.4. (B, top) Current traces of Chim6 and mSlo1 at [Ca²⁺]_i of 0, 10, and 500 μM. Test potentials were −80 to +200 mV, holding and repolarization potentials were −50 mV. (Bottom) Steady-state G-V relations of Chim6 and mSlo1. Smooth curves are fits of the Boltzmann equation with parameters for Chim6, in 0 [Ca²⁺]_i: V_1/2 = 206.7 mV, z = 1.3, in 10 μM [Ca²⁺]_i: V_1/2 = 101.1 mV, z = 1.2, in 500 μM [Ca²⁺]_i: V_1/2 = 52.5 mV, z = 1.2; for mSlo1, in 0 [Ca²⁺]_i: V_1/2 = 189.7 mV, z = 1.1, in 10 μM [Ca²⁺]_i: V_1/2 = 33.8 mV, z = 1.7, in 500 μM [Ca²⁺]_i: V_1/2 = −13.2 mV, z = 1.8.