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. 2005 Sep;126(3):213–226. doi: 10.1085/jgp.200509287

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Copyright © 2005, The Rockefeller University Press

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Figure 6. — The G466A/V467G mutations have little effect on single channel conductance. (A) Examples of single channel openings in response to steps to +80 mV from a holding potential of −70 mV in cell-attached patches. Low-pass filter, 2 kHz. Data from these two patches were fit by amplitude histograms producing estimates of 2.01 pA for WT and 2.22 pA for G466A/V467G. (B) Nonstationary noise analysis for depolarizations to +80 mV in two cell-attached patches, 10 kHz low-pass filter. Estimates of single channel current i amplitude and P _open,max are shown. Estimates of i and P _open,max in nine WT patches were 1.84 ± 0.07 pA and 0.78 ± 0.01, respectively. In six G466A/V467G patches the estimates of i and P _open,max were 2.30 ± 0.09 pA and 0.68 ± 0.02, respectively.