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. 2005 Sep;126(3):285–299. doi: 10.1085/jgp.200509289

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — Exceptional slowed gating kinetics in only the positive-charged 334R and 334K channels. (A) Parental control ΔC26 channels without SUR show fast burst exit gating, observed as very short bursts of one to several openings and a P_O ∼0.08. (B) For arginine at position 334, 6 of 11 patches exhibited dramatically slowed gating. (C) For the lysine mutant, 6 of 10 patches showed the fast gating, and 4 of 10 patches the slowed gating. On average, the exceptional slowed gating for either positive-charged substitution at 334 was characterized by approximately fivefold increase in P_O, from ∼0.1 to ∼0.5. During these initial experiments, interconversions between the fast and slow gating conformations were not observed and could not be induced by a variety of bath solutions.