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. 2005 Sep;126(3):285–299. doi: 10.1085/jgp.200509289

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Copyright © 2005, The Rockefeller University Press

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Figure 8. — Native slow burst exit gating in wild-type SUR1/K_ir6.2 channels also is speeded by protamine. (A) Wild-type SUR1/K_ir6.2 channels in the absence of ATP with typical slow gating from the burst, before and after bath application of 50 μM protamine to the inside-out patch. The protamine effect was easily washed out in the patches studied. Mean burst duration analysis of wild-type SUR1/K_ir6.2, before (B) and after (D) the protamine effect. On average the protamine decreased mean burst time from 48.0 ± 7.4 ms to 2.6 ± 0.9 (n = 5). Mean open duration analysis of wild-type SUR1/K_ir6.2, before (C) and after (E) the protamine effect. On average the protamine decreased mean open time from 2.1 ± 0.2 ms to 1.0 ± 0.2 ms (n = 5).