Table 2.

Hazard Ratios for Incident Probable Alzheimer’s Disease by Frequency of Intake of Tea, Sake, and Fruit and Vegetable Juices Among 1589 Subjects 65 Years and Older (the Kame Project 1992–2001)

	Intake frequency
	Less Often Than Weekly HR	1–2 Times per Week HR (95% CI)	3 Times or More per Week HR (95% CI)	P for Trend
Fruit and vegetable juice
Cases/unaffected	30/517	11/246	22/763
Model 1*	1.00	0.89 (0.44–1.79)	0.49 (0.28–0.86)	.01
Model 2†	1.00	0.74 (0.28–1.94)	0.28 (0.13–0.63)	< .01
Model 3‡	1.00	0.84 (0.31–2.29)	0.24 (0.09–0.61)	< .01
Tea drinking
Cases/unaffected	9/306	8/165	46/1056
Model 1*	1.00	2.00 (0.76–5.24)	1.29 (0.63–2.64)	.69
Model 2†	1.00	1.24 (0.37–4.22)	1.61 (0.64–4.05)	.29
Model 3‡	1.00	1.49 (0.43–5.16)	1.70 (0.67–4.33)	.27
Wine (sake) drinking§
Cases/unaffected	60/1412	0/45	2/54
Model 1*	1.00	0.49 (0.11–2.10)
Model 2†	1.00	0.10 (0.00–2.28)
Model 3‡	1.00	0.09 (0.01–1.43)

HR = hazard ratio; CI = confidence interval.

^*Adjusted for years of education in model 1.

^†Additionally adjusted for gender, regular physical activity, body mass index, baseline CASI score, olfaction diagnostic group, total energy intake, intake of saturated, monounsaturated, and polyunsaturated fatty acids, ApoE genotype, smoking status, alcohol drinking, supplementation of vitamin C, vitamin E, and multivitamin, and tea drinking, and fruit and vegetable juice drinking in model 2.

^‡Further adjusted for dietary intake of vitamin C, vitamin E, and β-carotene in model 3.

^§Only two categories were used because the number of cases was too small in one category and alcohol drinking was not adjusted in the model.