Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Dec;126(6):541–549. doi: 10.1085/jgp.200509380

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 5. — Negative charges at the D172 position, but not E224/E299, are required for the polyamine-induced stabilization of channel open state. (A) Current traces recorded from E224G/E299S mutant channels showing neomycin (Neo) sensitivities in the presence or absence of 100 μM DA10. (B) Normalized current (I/I₀)–concentration relationships for neomycin in the E224G/E299S, in the absence (ctl) and presence of 100 μM DA10. Numbers of patches and mean IC₅₀ are indicated in the legends. (C and D) Same as A and B, except for D172N mutant channels.