Figure 1.

Multipoint nonparametric linkage analysis of all families, CD-only families, mixed (families containing at least one or more member with a diagnosis of CD and one or more member with a diagnosis of UC, or any member with indeterminate idiopathic colitis) and UC-only families. The all-families curves reflect the combined contributions of the CD-only families, UC-only families, and mixed families. Map distances were taken from the Weber screening set 8.0. Multipoint analysis was performed by using a modified version of genehunter (25). Information content was 0.48, SD 0.07. ∗, regions implicated in Hugot et al.’s genome-wide screen (16). +, regions implicated in Satsangi et al.’s genome-wide screen (20). MHC, major histocompatibility complex.